![]() ![]() ![]() This is thought to occur at around early pregnancy (~6-7 weeks). An early vascular insult to the developing ureteric bud has been proposed 4.Įmbryologically renal agenesis results from a failure of the proper development of the metanephros (the future definitive adult kidney) resulting in the complete absence of a renal structure. The etiology in many cases of renal agenesis is currently unknown 7 but is thought to be multifactorial. ![]() As a result, severe oligemia is present with the main resultant abnormality being pulmonary hypoplasia. With no kidneys, the fetus is unable to produce urine, which is necessary to form amniotic fluid resulting in anhydramnios. Those with bilateral renal agenesis often have additional birth defects, both associated with, and a result of the absence of kidneys. Occasionally patients with unilateral renal agenesis, develop secondary hypertension. Unless identified on antenatal screening, then it is found incidentally when the abdomen is imaged for other reasons. If renal agenesis is unilateral and isolated then patients are asymptomatic. There may be a slightly greater male predilection. Unilateral renal agenesis affects approximately 1 in 500 live births while bilateral agenesis is less common affecting approximately 1 in 4000 live births. ![]()
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